Cytotoxic Chlorin e6 Derivatives with One or Two 4,5-Dichloro-1,2-thiazole Fragments

D. V. Belykh, M. V. Malshakova, A. V. Kletskov, E. S. Ivanova, Y. V. Dutikova, V. I. Potkin, and A. A. Shtil

We report the synthesis of chlorin е₆ derivatives with one or two 4,5-dichloro-1,2-thiazole fragments. The chlorin and dichloroisothiazole cycles were conjugated by acylation of amino groups in peripheral substituents of the chlorin macrocycle with chloroanhydride of 3-carboxy-4,5-dichloro-1,2-thiazole. At micromolar concentrations the new compounds evoked dark cytotoxicity for the human colon carcinoma cell line.